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Welcome to our FAQ page, where you can find answers to the most commonly asked
1. Feminine Suppositories
2. Pregnancy & Nursing
Feminine Suppositories
What is vaginal microbiome?
Just like the gut, the vaginal tissue consists of trillions of microorganisms - mostly bacteria, plus some fungi and viruses. Together, these populations make up the vaginal microbiome.
But why should I care about my vaginal microbiome?
There’s an immense amount of research that is now showing just how important our vaginal microbiomes are and just how personalized our approaches to managing them should be. Imbalanced vaginal microbiome profiles have been shown to be associated with increased rates of bacterial vaginosis, infertility, preterm birth, and increased risk of STD susceptibility.
Why am I only just hearing about the vaginal microbiome?
The vaginal microbiome and its impact on women’s health and fertility is only just being unraveled. Research in this space has lagged behind the gut microbiome but very recent work is showing its importance in things like infections, fertility, and preterm birth.
Recurrent bacterial vaginosis, does this have to do something with my vaginal microbiome?
Yes, indeed; bacterial vaginosis is a condition in which the vaginal microbiome is imbalanced. An imbalanced vaginal microbiome often contains ‘bad bacteria’ that cause a biofilm to form. Oftentimes, antibiotics alone are not enough to disrupt this biofilm and help you get rid of bacterial vaginosis. Understanding what’s in your vaginal microbiome can help you and your doctor work toward the best solution for you.
Why use Biom's vaginal suppository to balance the vaginal microbiome?
Suppositories offer more bioavailability through the vagina, as opposed to many oral supplements, the benefits of which cannot be realized due to liver metabolism and digestive enzymes. Our proprietary strains of Lactobacillus crispatus Bi16 and Lactobacillus gasseri Bi19 are from healthy human commensal flora that inhibits pathogens with high colonization capacity.
Biom’s developed a powerful synergistic combination of vaginal probiotics, prebiotics, and lactic acid for the vaginal microflora. The formulation also has hyaluronic acid that has the capacity to moisturize the vaginal for hydration and lubrication. Our patented microbiome Biomsify® fermentation technology allows vaginal tissue-adapted probiotic flora to maximally adhere and colonize the vaginal tissue.
Is Biom's vaginal suppository safe to use?
All the ingredients used in Biom Vaginal Suppository are safe compounds that mostly originated from organic vegan sources. It includes coconut fatty acids, hyaluronic acid, natural moisturizing complex, patented Biomsify® Probiotics-Prebiotics Complex 10 billion flora (Lactobacillus acidophilus Bi14, Lactobacillus crispatus Bi16, Bacillus coagulans Bi34, Lactobacillus gasseri Bi19, lactose, enzyme-hydrolyzed cellulose, oligofructose, silica gel), lactic acid, organic natural jasmine oil.
Who makes Biom's vaginal suppositories?
Probiotic Vaginal Suppositories are developed and manufactured by Biom Pharmaceutical Corporation, a research-based biopharmaceutical company focused on the human microbiome.
Pregnancy & Nursing
What is Avazza?
Avazza is a Once Daily Prenatal hypoallergenic probiotic supplement and a prebiotic supplement, with 500mg Human Milk Oligosaccharide (HMOs) prebiotic fiber to help feed good bacteria in the gut.
The powerful Postbiotics stabilize beneficial flora. Biom uses clinically studied CARE4U brand HMD with resistant starch and soluble prebiotics, these probiotics are helpful to heal the gut lining stabilizing and nurturing the gut microbiome.
What does Avazza do in the gut?
This synergistic formulation with probiotics, prebiotics, and postbiotics can increase microbial diversity and selectively feed beneficial gut health-enhancing microflora.
The HMOs in Avazza assist in the repair of your stomach’s lining and helps build natural protection against annoying and unhealthy symptoms and digestive issues such as a leaky gut.
A leaky gut is when the lining is damaged and cannot optimally function as a barrier any longer. The smaller holes become larger and allow harmful substances like gluten, bad bacteria, and undigested food particles to enter your system and cause considerable damage to your health.
Once Daily beverage mix provides 10 Billion CFU, Probiotic + Prebiotic Fiber, and Postbiotics support optimal gut health during pregnancy and lactation.
What are Human Milk Oligosaccharides (HMOs)?
Human milk oligosaccharides, otherwise known as HMOs, are a very special type of prebiotic found in mothers’ brealk. In fact, they are the largest solid component of breast milk after carbohydrates and fat.
Biotechnologists produce HMOs enzymes using an innovative fermentation process. These biotechnologically produced sugars are chemically identical to their models in human breast milk and are used to promote a healthy gut microbiome.
How do HMOs function in the body?
After ingestion, human milk oligosaccharides (HMOs) are resistant to digestion in the upper gastrointestinal tract, which allows them to reach the lower digestive tract fully intact. Once there, HMOs serve as natural prebiotics, or ’food’ for probiotics. As such, they support gut microbiome’s growth and development. HMOs have been shown to support intestinal integrity, brain development, cognitive capacities and immune health. They impact the natural development of the neonatal microbiome.
HMOs have been scientifically studied to support the development of normal immune and digestive systems in preterm infants.
The HMOs assist in the repair of your stomach’s lining and helps build natural protection against annoying, unhealthy symptoms and digestive issues such as a leaky gut.
What are the benefits of Human Milk Oligosaccharides?
HMOs have been shown to support intestinal integrity, brain development, cognitive capacities and immune health. They impact the natural development of the neonatal microbiome.
HMOs can help to rebuild gut lining. A leaky gut is when the lining is damaged and cannot optimally function as a barrier any longer. The smaller holes become larger and allow harmful substances like gluten, bad bacteria, and undigested food particles to enter your system and cause considerable damage to your health.
How does Avazza and HMOs work?
HMOs are indigestible by the human body. When they reach the colon, they are broken down by the microbiota there. Bifidobacterium spp. and Bacteroides spp. both produce enzymes that are particularly effective at this. The HMOs can then be consumed by other ‘good’ gut bacteria, helping to promote gut health. HMOs also stimulate the gut bacteria to produce short-chain fatty acids, which strengthen the gut’s mucous membrane. This mucosal barrier protects which substances are absorbed into the human body while letting nutrients pass.
Avazza with HMOs may support immune function. Probiotics can help increase pathogen recognition (part of the innate immune response) and may also provide antimicrobial and antiviral activity.
Why are probiotics and prebiotics important during the prenatal and nursing stages of childbirth?
Probiotics are popular supplements that are safe to take if you’re pregnant or breastfeeding. In fact, taking them during pregnancy has been linked to benefits like fewer pregnancy complications, reduced risk of eczema in babies, and improved markers of metabolic health in expectant mothers.
Human milk oligosaccharides play a key role in the maturation of the infant gut microbiome and immune system and are hypothesized to affect growth.
HMOs contribute to the development of the infant’s microflora and immune system. By acting via various mechanisms, they protect against many infections and alleviate their course. They have been shown to have anti-bacterial, anti-viral, and anti-inflammatory effects.
How do HMO’s benefit infants?
Human milk oligosaccharides (HMOs) may support three primary benefits for developing infants: digestive health, immune support, and cognitive development.
Why is a balanced flora important during pregnancy?
Regulating gut microbiomes is beneficial to the health of the mother and the fetus. In addition, many complications during pregnancy are related to gut microbiomes, such as gestational diabetes, obesity, preeclampsia, digestive disorders, and autoimmune diseases.
Who is Avazza made for?
Avazza was developed for Pregnant and Nursing Mothers, however, anyone can benefit from the product on a regular basis. It will help improve and increase gut microbiome diversity for your entire family. It is safe for children over 3 years old and adults in any stage of life.
What are the ingredients in Avazza?
Human Milk Oligosaccharides, Soluble prebiotics, Galactomannan, Organic Natural Citrus Flavor, Organic Stevia extract.
How often and how much Azazza should I take?
Once Daily beverage mix provides 10 Billion CFU, Probiotic + Prebiotic Fiber, and Postbiotics for optimal gut health support during pregnancy and lactation.
Start with ½ scoop daily for one week, then increase to 1 scoop daily with or without food, or as directed by your healthcare practitioner. Mix 5 grams into 16 oz of cold water or a beverage of your choice. 100% Vegan, Non-GMO, Gluten-Free.
How are Human Milk Oligosaccharides produced?
Human milk oligosaccharides are produced by an innovative fermentation process based on scientific research and results. To achieve this, the bacteria strain E. coli B21 is genetically modified by biotechnologists so that these bacteria produce the enzymes necessary to form HMOs.
Does natural breast milk contain oligosaccharides?
The composition of breast milk is highly complex, as it contains numerous biomolecules. Human breast milk has 2 types of carbohydrates: lactose and oligosaccharides.
Human milk oligosaccharides (HMOs) are a very important and interesting constituent of human milk and are the third most abundant solid component after lactose and lipids. They are a structurally and biologically diverse group of complex indigestible sugars.
In breastfed babies, HMOs are scientifically shown to positively affect the microbiome.
Does Human Milk Oligosaccharides provide Immune support for unborn babies?
Research is showing that HMOs are a key ingredient for infants. Rachael Buck, a research scientist, and immune expert at Abbott has studied the components of breast milk for more than 20 years.
About 70 percent of the immune system resides in the gut, so it’s crucial to give your baby the building blocks they need from the start. Probiotics, also known as beneficial bacteria, are live microorganisms located in the intestinal tract. Prebiotics are not bacteria, but they provide the food source that probiotics need to survive.
What is the Role of Human Milk Oligosaccharides (HMOs) in Infant Heath?
Human milk oligosaccharides (HMOs) are complex indigestible sugars naturally present in breast milk. They are particularly interesting because of their quantity and structural diversity, which underpins multiple beneficial benefits to the health of babies.
They are well-known for their prebiotic effect in infants, where they serve as food for intestinal bacteria, especially bifidobacteria. The dominance of these intestinal bacteria in the gut ensures healthy intestinal microbiota and reduces the risk of dangerous intestinal infections in infants.
Is Human Milk Oligosaccharides good for irritable bowel syndrome?
Research has shown that the gut microbiota of patients with irritable bowel syndrome (IBS) lack a healthy abundance of bifidobacteria. Human milk oligosaccharides (HMOs) may help boost bifidobacteria and may also have a beneficial impact on gut motility and visceral pain, according to a new multi-center, open-label trial in patients with IBS.
In results presented at the American College of Gastroenterology’s Annual Scientific Meeting (ACG 2019) in San Antonio, Texas, investigators report the ability of HMOs to support normal bowel habits and improve other symptoms of IBS.
There is a lot of evidence from research studies that indicate altered composition and function of the gut bacteria is of importance for symptoms in at least a subset of patients with IBS. This means that by altering the gut microbiota composition and/or function through different treatment modalities, symptom improvement can be expected.
Are there any negative effects of consuming Human Milk Oligosaccharides?
Oligosaccharides are generally considered safe but can cause bloating, cramping, gas, or diarrhea in some people. To minimize symptoms, increase your intake of oligosaccharide-rich foods gradually, such as leeks, garlic, asparagus, kale, cabbage, broccoli, legumes, jicama, and other plant foods. You also can find oligosaccharides in berries, pears, figs, bananas, nectarines, and watermelon as well as in wheat, rye, peas, and beans.
Can Avazza be given to young children?
Yes, children over 3 years old can safely consume Avazza to help improve gut health.
Can Avazza be used to improve gut lining integrity?
Advanced technology has shown that the fermentation products of HMOs made the gut lining less “leaky.” A leaky intestinal barrier has been linked to gut conditions such as coeliac disease, Crohn’s disease, and irritable bowel syndrome as well as a range of conditions affecting the rest of the body.
These studies provide scientific evidence that HMOs may be used to develop strategies to counter these conditions and improve gut health in adults.
A little SCIENCE HERE! A Recent clinical Trial…
A recent clinical trial showed that two specific HMOs, 2′-O-fucosyllactose (2’FL) and/or lacto-N-neotetraose (LNnT), are safe and well-tolerated in adults and are modulators of the adult gut microbiota with an increase in bifidobacteria.
This suggests that HMO supplementation may be a valuable strategy to modulate health in adults.
To address this, a collaboration was established between the Quadram Institute, a food and health research center in the Norwich Research Park, UK, and Glycom, a Danish-based biotechnology company, and the world’s leading supplier of HMOs.
Their study, published in the journal Nutrients, was partly funded by the Biotechnology and Biological Sciences Research Council (BBSRC).
A Simulator of the Human Intestinal Microbial Ecosystem (SHIME®) was used to determine the influence of HMOs on the adult gut microbiota composition and function.
These experiments were performed at ProDigest, a spin-off company from the Center of Microbial Ecology and Technology (CMET), located at Ghent University in Belgium.
The results showed that fermentation of 2’FL, LNnT and combinations thereof led to an increase of bifidobacteria, accompanied by an increase of short-chain fatty acids.
Prof. Nathalie Juge’s team in the Quadram Institute then used the products of this fermentation to study the influence of fermented HMOs on the intestinal barrier function of cell lines and advanced gut-on-chip models.
Caco2 cells are a line of cells originally derived from the human gut and used extensively in research, with an arrangement of them into a single layer being an established model for studying the gut and its permeability.
A significant reduction in permeability was observed using Caco2 cell monolayers with fermented HMOs, accompanied by an increase in specific proteins known to help maintain barrier integrity, tight-junction proteins, and cytokines.
1. Feminine Suppositories
2. Pregnancy & Nursing
Feminine Suppositories
What is vaginal microbiome?
Just like the gut, the vaginal tissue consists of trillions of microorganisms — mostly bacteria, plus some fungi and viruses. Together, these populations make up the vaginal microbiome.
But why should I care about my vaginal microbiome?
There’s an immense amount of research that is now showing just how important our vaginal microbiomes are and just how personalized our approaches to managing them should be. Imbalanced vaginal microbiome profiles have been shown to be associated with increased rates of bacterial vaginosis, infertility, preterm birth, and increased risk of STD susceptibility.
Why am I only just hearing about the vaginal microbiome?
The vaginal microbiome and its impact on women’s health and fertility is only just being unraveled. Research in this space has lagged behind the gut microbiome but very recent work is showing its importance in things like infections, fertility, and preterm birth.
Recurrent bacterial vaginosis, does this have to do something with my vaginal microbiome?
Yes, indeed; bacterial vaginosis is a condition in which the vaginal microbiome is imbalanced. An imbalanced vaginal microbiome often contains ‘bad bacteria’ that cause a biofilm to form. Oftentimes, antibiotics alone are not enough to disrupt this biofilm and help you get rid of bacterial vaginosis. Understanding what’s in your vaginal microbiome can help you and your doctor work toward the best solution for you.
Why use Biom's vaginal suppository to balance the vaginal microbiome?
Suppositories offer more bioavailability through the vagina, as opposed to many oral supplements, the benefits of which cannot be realized due to liver metabolism and digestive enzymes. Our proprietary strains of Lactobacillus crispatus Bi16 and Lactobacillus gasseri Bi19 are from healthy human commensal flora that inhibits pathogens with high colonization capacity.
Biom’s developed a powerful synergistic combination of vaginal probiotics, prebiotics, and lactic acid for the vaginal microflora. The formulation also has hyaluronic acid that has the capacity to moisturize the vaginal for hydration and lubrication. Our patented microbiome Biomsify® fermentation technology allows vaginal tissue-adapted probiotic flora to maximally adhere and colonize the vaginal tissue.
Is Biom's vaginal suppository safe to use?
All the ingredients used in Biom Vaginal Suppository are safe compounds that mostly originated from organic vegan sources. It includes coconut fatty acids, hyaluronic acid, natural moisturizing complex, patented Biomsify® Probiotics-Prebiotics Complex 10 billion flora (Lactobacillus acidophilus Bi14, Lactobacillus crispatus Bi16, Bacillus coagulans Bi34, Lactobacillus gasseri Bi19, lactose, enzyme-hydrolyzed cellulose, oligofructose, silica gel), lactic acid, organic natural jasmine oil.
Who makes Biom's vaginal suppositories?
Probiotic Vaginal Suppositories are developed and manufactured by Biom Pharmaceutical Corporation, a research-based biopharmaceutical company focused on the human microbiome.
Pregnancy & Nursing
What is Avazza?
Avazza is a Once Daily Prenatal hypoallergenic probiotic supplement and a prebiotic supplement, with 500mg Human Milk Oligosaccharide (HMOs) prebiotic fiber to help feed good bacteria in the gut.
The powerful Postbiotics stabilize beneficial flora. Biom uses clinically studied CARE4U brand HMD with resistant starch and soluble prebiotics, these probiotics are helpful to heal the gut lining stabilizing and nurturing the gut microbiome.
What does Avazza do in the gut?
This synergistic formulation with probiotics, prebiotics, and postbiotics can increase microbial diversity and selectively feed beneficial gut health-enhancing microflora.
The HMOs in Avazza assist in the repair of your stomach’s lining and helps build natural protection against annoying and unhealthy symptoms and digestive issues such as a leaky gut.
A leaky gut is when the lining is damaged and cannot optimally function as a barrier any longer. The smaller holes become larger and allow harmful substances like gluten, bad bacteria, and undigested food particles to enter your system and cause considerable damage to your health.
Once Daily beverage mix provides 10 Billion CFU, Probiotic + Prebiotic Fiber, and Postbiotics support optimal gut health during pregnancy and lactation.
What are Human Milk Oligosaccharides (HMOs)?
Human milk oligosaccharides*, otherwise known as HMOs, are a very special type of prebiotic found in mothers’ brealk. In fact, they are the largest solid component of breast milk after carbohydrates and fat.
Biotechnologists produce HMOs enzymes using an innovative fermentation process. These biotechnologically produced sugars are chemically identical to their models in human breast milk and are used to promote a healthy gut microbiome.
How do HMOs function in the body?
After ingestion, human milk oligosaccharides (HMOs) are resistant to digestion in the upper gastrointestinal tract, which allows them to reach the lower digestive tract fully intact. Once there, HMOs serve as natural prebiotics, or ’food’ for probiotics. As such, they support gut microbiome’s growth and development. HMOs have been shown to support intestinal integrity, brain development, cognitive capacities and immune health. They impact the natural development of the neonatal microbiome.
HMOs have been scientifically studied to support the development of normal immune and digestive systems in preterm infants.
The HMOs assist in the repair of your stomach’s lining and helps build natural protection against annoying, unhealthy symptoms and digestive issues such as a leaky gut.
What are the benefits of Human Milk Oligosaccharides?
HMOs have been shown to support intestinal integrity, brain development, cognitive capacities and immune health. They impact the natural development of the neonatal microbiome.
HMOs can help to rebuild gut lining. A leaky gut is when the lining is damaged and cannot optimally function as a barrier any longer. The smaller holes become larger and allow harmful substances like gluten, bad bacteria, and undigested food particles to enter your system and cause considerable damage to your health.
How does Avazza and HMOs work?
HMOs are indigestible by the human body. When they reach the colon, they are broken down by the microbiota there. Bifidobacterium spp. and Bacteroides spp. both produce enzymes that are particularly effective at this. The HMOs can then be consumed by other ‘good’ gut bacteria, helping to promote gut health. HMOs also stimulate the gut bacteria to produce short-chain fatty acids, which strengthen the gut’s mucous membrane. This mucosal barrier protects which substances are absorbed into the human body while letting nutrients pass.
Avazza with HMOs may support immune function. Probiotics can help increase pathogen recognition (part of the innate immune response) and may also provide antimicrobial and antiviral activity.
Why are probiotics and prebiotics important during the prenatal and nursing stages of childbirth?
Probiotics are popular supplements that are safe to take if you’re pregnant or breastfeeding. In fact, taking them during pregnancy has been linked to benefits like fewer pregnancy complications, reduced risk of eczema in babies, and improved markers of metabolic health in expectant mothers.
Human milk oligosaccharides play a key role in the maturation of the infant gut microbiome and immune system and are hypothesized to affect growth.
HMOs contribute to the development of the infant’s microflora and immune system. By acting via various mechanisms, they protect against many infections and alleviate their course. They have been shown to have anti-bacterial, anti-viral, and anti-inflammatory effects.
How do HMO’s benefit infants?
Human milk oligosaccharides (HMOs) may support three primary benefits for developing infants: digestive health, immune support, and cognitive development.
Why is a balanced flora important during pregnancy?
Regulating gut microbiomes is beneficial to the health of the mother and the fetus. In addition, many complications during pregnancy are related to gut microbiomes, such as gestational diabetes, obesity, preeclampsia, digestive disorders, and autoimmune diseases.
Who is Avazza made for?
Avazza was developed for Pregnant and Nursing Mothers, however, anyone can benefit from the product on a regular basis. It will help improve and increase gut microbiome diversity for your entire family. It is safe for children over 3 years old and adults in any stage of life.
What are the ingredients in Avazza?
Human Milk Oligosaccharides, Soluble prebiotics, Galactomannan, Organic Natural Citrus Flavor, Organic Stevia extract
How often and how much Azazza should I take?
Once Daily beverage mix provides 10 Billion CFU, Probiotic + Prebiotic Fiber, and Postbiotics for optimal gut health support during pregnancy and lactation.
Start with ½ scoop daily for one week, then increase to 1 scoop daily with or without food, or as directed by your healthcare practitioner. Mix 5 grams into 16 oz of cold water or a beverage of your choice. 100% Vegan, Non-GMO, Gluten-Free
How are Human Milk Oligosaccharides produced?
Human milk oligosaccharides are produced by an innovative fermentation process based on scientific research and results. To achieve this, the bacteria strain E. coli B21 is genetically modified by biotechnologists so that these bacteria produce the enzymes necessary to form HMOs.
Does natural breast milk contain oligosaccharides?
The composition of breast milk is highly complex, as it contains numerous biomolecules. Human breast milk has 2 types of carbohydrates: lactose and oligosaccharides.
Human milk oligosaccharides (HMOs) are a very important and interesting constituent of human milk and are the third most abundant solid component after lactose and lipids. They are a structurally and biologically diverse group of complex indigestible sugars.
In breastfed babies, HMOs are scientifically shown to positively affect the microbiome.
Does Human Milk Oligosaccharides provide Immune support for unborn babies?
Research is showing that HMOs are a key ingredient for infants. Rachael Buck, a research scientist, and immune expert at Abbott has studied the components of breast milk for more than 20 years.
About 70 percent of the immune system resides in the gut, so it’s crucial to give your baby the building blocks they need from the start. Probiotics, also known as beneficial bacteria, are live microorganisms located in the intestinal tract. Prebiotics are not bacteria, but they provide the food source that probiotics need to survive.
What is the Role of Human Milk Oligosaccharides (HMOs) in Infant Heath?
Human milk oligosaccharides (HMOs) are complex indigestible sugars naturally present in breast milk. They are particularly interesting because of their quantity and structural diversity, which underpins multiple beneficial benefits to the health of babies.
They are well-known for their prebiotic effect in infants, where they serve as food for intestinal bacteria, especially bifidobacteria. The dominance of these intestinal bacteria in the gut ensures healthy intestinal microbiota and reduces the risk of dangerous intestinal infections in infants.
Is Human Milk Oligosaccharides good for irritable bowel syndrome?
Research has shown that the gut microbiota of patients with irritable bowel syndrome (IBS) lack a healthy abundance of bifidobacteria. Human milk oligosaccharides (HMOs) may help boost bifidobacteria and may also have a beneficial impact on gut motility and visceral pain, according to a new multi-center, open-label trial in patients with IBS.
In results presented at the American College of Gastroenterology’s Annual Scientific Meeting (ACG 2019) in San Antonio, Texas, investigators report the ability of HMOs to support normal bowel habits and improve other symptoms of IBS.
There is a lot of evidence from research studies that indicate altered composition and function of the gut bacteria is of importance for symptoms in at least a subset of patients with IBS. This means that by altering the gut microbiota composition and/or function through different treatment modalities, symptom improvement can be expected.
Are there any negative effects of consuming Human Milk Oligosaccharides?
Oligosaccharides are generally considered safe but can cause bloating, cramping, gas, or diarrhea in some people. To minimize symptoms, increase your intake of oligosaccharide-rich foods gradually, such as leeks, garlic, asparagus, kale, cabbage, broccoli, legumes, jicama, and other plant foods. You also can find oligosaccharides in berries, pears, figs, bananas, nectarines, and watermelon as well as in wheat, rye, peas, and beans.
Can Avazza be given to young children?
Yes, children over 3 years old can safely consume Avazza to help improve gut health.
Can Avazza be used to improve gut lining integrity?
Advanced technology has shown that the fermentation products of HMOs made the gut lining less “leaky.” A leaky intestinal barrier has been linked to gut conditions such as coeliac disease, Crohn’s disease, and irritable bowel syndrome as well as a range of conditions affecting the rest of the body.
These studies provide scientific evidence that HMOs may be used to develop strategies to counter these conditions and improve gut health in adults.
A little SCIENCE HERE! A Recent clinical Trial…
A recent clinical trial showed that two specific HMOs, 2′-O-fucosyllactose (2’FL) and/or lacto-N-neotetraose (LNnT), are safe and well-tolerated in adults and are modulators of the adult gut microbiota with an increase in bifidobacteria.
This suggests that HMO supplementation may be a valuable strategy to modulate health in adults.
To address this, a collaboration was established between the Quadram Institute, a food and health research center in the Norwich Research Park, UK, and Glycom, a Danish-based biotechnology company, and the world’s leading supplier of HMOs.
Their study, published in the journal Nutrients, was partly funded by the Biotechnology and Biological Sciences Research Council (BBSRC).
A Simulator of the Human Intestinal Microbial Ecosystem (SHIME®) was used to determine the influence of HMOs on the adult gut microbiota composition and function.
These experiments were performed at ProDigest, a spin-off company from the Center of Microbial Ecology and Technology (CMET), located at Ghent University in Belgium.
The results showed that fermentation of 2’FL, LNnT and combinations thereof led to an increase of bifidobacteria, accompanied by an increase of short-chain fatty acids.
Prof. Nathalie Juge’s team in the Quadram Institute then used the products of this fermentation to study the influence of fermented HMOs on the intestinal barrier function of cell lines and advanced gut-on-chip models.
Caco2 cells are a line of cells originally derived from the human gut and used extensively in research, with an arrangement of them into a single layer being an established model for studying the gut and its permeability.
A significant reduction in permeability was observed using Caco2 cell monolayers with fermented HMOs, accompanied by an increase in specific proteins known to help maintain barrier integrity, tight-junction proteins, and cytokines.
1. Feminine Suppositories
2. Pregnancy & Nursing
Feminine Suppositories
What is vaginal microbiome?
Just like the gut, the vaginal tissue consists of trillions of microorganisms — mostly bacteria, plus some fungi and viruses. Together, these populations make up the vaginal microbiome.
But why should I care about my vaginal microbiome?
There’s an immense amount of research that is now showing just how important our vaginal microbiomes are and just how personalized our approaches to managing them should be. Imbalanced vaginal microbiome profiles have been shown to be associated with increased rates of bacterial vaginosis, infertility, preterm birth, and increased risk of STD susceptibility.
Why am I only just hearing about the vaginal microbiome?
The vaginal microbiome and its impact on women’s health and fertility is only just being unraveled. Research in this space has lagged behind the gut microbiome but very recent work is showing its importance in things like infections, fertility, and preterm birth.
Recurrent bacterial vaginosis, does this have to do something with my vaginal microbiome?
Yes, indeed; bacterial vaginosis is a condition in which the vaginal microbiome is imbalanced. An imbalanced vaginal microbiome often contains ‘bad bacteria’ that cause a biofilm to form. Oftentimes, antibiotics alone are not enough to disrupt this biofilm and help you get rid of bacterial vaginosis. Understanding what’s in your vaginal microbiome can help you and your doctor work toward the best solution for you.
Why use Biom's vaginal suppository to balance the vaginal microbiome?
Suppositories offer more bioavailability through the vagina, as opposed to many oral supplements, the benefits of which cannot be realized due to liver metabolism and digestive enzymes. Our proprietary strains of Lactobacillus crispatus Bi16 and Lactobacillus gasseri Bi19 are from healthy human commensal flora that inhibits pathogens with high colonization capacity.
Biom’s developed a powerful synergistic combination of vaginal probiotics, prebiotics, and lactic acid for the vaginal microflora. The formulation also has hyaluronic acid that has the capacity to moisturize the vaginal for hydration and lubrication. Our patented microbiome Biomsify® fermentation technology allows vaginal tissue-adapted probiotic flora to maximally adhere and colonize the vaginal tissue.
Is Biom's vaginal suppository safe to use?
All the ingredients used in Biom Vaginal Suppository are safe compounds that mostly originated from organic vegan sources. It includes coconut fatty acids, hyaluronic acid, natural moisturizing complex, patented Biomsify® Probiotics-Prebiotics Complex 10 billion flora (Lactobacillus acidophilus Bi14, Lactobacillus crispatus Bi16, Bacillus coagulans Bi34, Lactobacillus gasseri Bi19, lactose, enzyme-hydrolyzed cellulose, oligofructose, silica gel), lactic acid, organic natural jasmine oil.
Who makes Biom's vaginal suppositories?
Probiotic Vaginal Suppositories are developed and manufactured by Biom Pharmaceutical Corporation, a research-based biopharmaceutical company focused on the human microbiome.
Pregnancy & Nursing
What is Avazza?
Avazza is a Once Daily Prenatal hypoallergenic probiotic supplement and a prebiotic supplement, with 500mg Human Milk Oligosaccharide (HMOs) prebiotic fiber to help feed good bacteria in the gut.
The powerful Postbiotics stabilize beneficial flora. Biom uses clinically studied CARE4U brand HMD with resistant starch and soluble prebiotics, these probiotics are helpful to heal the gut lining stabilizing and nurturing the gut microbiome.
What does Avazza do in the gut?
This synergistic formulation with probiotics, prebiotics, and postbiotics can increase microbial diversity and selectively feed beneficial gut health-enhancing microflora.
The HMOs in Avazza assist in the repair of your stomach’s lining and helps build natural protection against annoying and unhealthy symptoms and digestive issues such as a leaky gut.
A leaky gut is when the lining is damaged and cannot optimally function as a barrier any longer. The smaller holes become larger and allow harmful substances like gluten, bad bacteria, and undigested food particles to enter your system and cause considerable damage to your health.
Once Daily beverage mix provides 10 Billion CFU, Probiotic + Prebiotic Fiber, and Postbiotics support optimal gut health during pregnancy and lactation.
What are Human Milk Oligosaccharides (HMOs)?
Human milk oligosaccharides*, otherwise known as HMOs, are a very special type of prebiotic found in mothers’ brealk. In fact, they are the largest solid component of breast milk after carbohydrates and fat.
Biotechnologists produce HMOs enzymes using an innovative fermentation process. These biotechnologically produced sugars are chemically identical to their models in human breast milk and are used to promote a healthy gut microbiome.
How do HMOs function in the body?
After ingestion, human milk oligosaccharides (HMOs) are resistant to digestion in the upper gastrointestinal tract, which allows them to reach the lower digestive tract fully intact. Once there, HMOs serve as natural prebiotics, or ‘food’ for probiotics. As such, they support gut microbiome’s growth and development. HMOs have been shown to support intestinal integrity, brain development, cognitive capacities and immune health. They impact the natural development of the neonatal microbiome.
HMOs have been scientifically studied to support the development of normal immune and digestive systems in preterm infants.
The HMOs assist in the repair of your stomach’s lining and helps build natural protection against annoying, unhealthy symptoms and digestive issues such as a leaky gut.
What are the benefits of Human Milk Oligosaccharides?
HMOs have been shown to support intestinal integrity, brain development, cognitive capacities and immune health. They impact the natural development of the neonatal microbiome.
HMOs can help to rebuild gut lining. A leaky gut is when the lining is damaged and cannot optimally function as a barrier any longer. The smaller holes become larger and allow harmful substances like gluten, bad bacteria, and undigested food particles to enter your system and cause considerable damage to your health.
How does Avazza and HMOs work?
HMOs are indigestible by the human body. When they reach the colon, they are broken down by the microbiota there. Bifidobacterium spp. and Bacteroides spp. both produce enzymes that are particularly effective at this. The HMOs can then be consumed by other ‘good’ gut bacteria, helping to promote gut health. HMOs also stimulate the gut bacteria to produce short-chain fatty acids, which strengthen the gut’s mucous membrane. This mucosal barrier protects which substances are absorbed into the human body while letting nutrients pass.
Avazza with HMOs may support immune function. Probiotics can help increase pathogen recognition (part of the innate immune response) and may also provide antimicrobial and antiviral activity.
Why are probiotics and prebiotics important during the prenatal and nursing stages of childbirth?
Probiotics are popular supplements that are safe to take if you’re pregnant or breastfeeding. In fact, taking them during pregnancy has been linked to benefits like fewer pregnancy complications, reduced risk of eczema in babies, and improved markers of metabolic health in expectant mothers.
Human milk oligosaccharides play a key role in the maturation of the infant gut microbiome and immune system and are hypothesized to affect growth.
HMOs contribute to the development of the infant’s microflora and immune system. By acting via various mechanisms, they protect against many infections and alleviate their course. They have been shown to have anti-bacterial, anti-viral, and anti-inflammatory effects.
How do HMO’s benefit infants?
Human milk oligosaccharides (HMOs) may support three primary benefits for developing infants: digestive health, immune support, and cognitive development.
Why is a balanced flora important during pregnancy?
Regulating gut microbiomes is beneficial to the health of the mother and the fetus. In addition, many complications during pregnancy are related to gut microbiomes, such as gestational diabetes, obesity, preeclampsia, digestive disorders, and autoimmune diseases.
Who is Avazza made for?
Avazza was developed for Pregnant and Nursing Mothers, however, anyone can benefit from the product on a regular basis. It will help improve and increase gut microbiome diversity for your entire family. It is safe for children over 3 years old and adults in any stage of life.
What are the ingredients in Avazza?
Human Milk Oligosaccharides, Soluble prebiotics, Galactomannan, Organic Natural Citrus Flavor, Organic Stevia extract.
How often and how much Azazza should I take?
Once Daily beverage mix provides 10 Billion CFU, Probiotic + Prebiotic Fiber, and Postbiotics for optimal gut health support during pregnancy and lactation.
Start with ½ scoop daily for one week, then increase to 1 scoop daily with or without food, or as directed by your healthcare practitioner. Mix 5 grams into 16 oz of cold water or a beverage of your choice. 100% Vegan, Non-GMO, Gluten-Free.
How are Human Milk Oligosaccharides produced?
Human milk oligosaccharides are produced by an innovative fermentation process based on scientific research and results. To achieve this, the bacteria strain E. coli B21 is genetically modified by biotechnologists so that these bacteria produce the enzymes necessary to form HMOs.
Does natural breast milk contain oligosaccharides?
The composition of breast milk is highly complex, as it contains numerous biomolecules. Human breast milk has 2 types of carbohydrates: lactose and oligosaccharides.
Human milk oligosaccharides (HMOs) are a very important and interesting constituent of human milk and are the third most abundant solid component after lactose and lipids. They are a structurally and biologically diverse group of complex indigestible sugars.
In breastfed babies, HMOs are scientifically shown to positively affect the microbiome.
Does Human Milk Oligosaccharides provide Immune support for unborn babies?
Research is showing that HMOs are a key ingredient for infants. Rachael Buck, a research scientist, and immune expert at Abbott has studied the components of breast milk for more than 20 years.
About 70 percent of the immune system resides in the gut, so it’s crucial to give your baby the building blocks they need from the start. Probiotics, also known as beneficial bacteria, are live microorganisms located in the intestinal tract. Prebiotics are not bacteria, but they provide the food source that probiotics need to survive.
What is the Role of Human Milk Oligosaccharides (HMOs) in Infant Heath?
Human milk oligosaccharides (HMOs) are complex indigestible sugars naturally present in breast milk. They are particularly interesting because of their quantity and structural diversity, which underpins multiple beneficial benefits to the health of babies.
They are well-known for their prebiotic effect in infants, where they serve as food for intestinal bacteria, especially bifidobacteria. The dominance of these intestinal bacteria in the gut ensures healthy intestinal microbiota and reduces the risk of dangerous intestinal infections in infants.
Is Human Milk Oligosaccharides good for irritable bowel syndrome?
Research has shown that the gut microbiota of patients with irritable bowel syndrome (IBS) lack a healthy abundance of bifidobacteria. Human milk oligosaccharides (HMOs) may help boost bifidobacteria and may also have a beneficial impact on gut motility and visceral pain, according to a new multi-center, open-label trial in patients with IBS.
In results presented at the American College of Gastroenterology’s Annual Scientific Meeting (ACG 2019) in San Antonio, Texas, investigators report the ability of HMOs to support normal bowel habits and improve other symptoms of IBS.
There is a lot of evidence from research studies that indicate altered composition and function of the gut bacteria is of importance for symptoms in at least a subset of patients with IBS. This means that by altering the gut microbiota composition and/or function through different treatment modalities, symptom improvement can be expected.
Are there any negative effects of consuming Human Milk Oligosaccharides?
Oligosaccharides are generally considered safe but can cause bloating, cramping, gas, or diarrhea in some people. To minimize symptoms, increase your intake of oligosaccharide-rich foods gradually, such as leeks, garlic, asparagus, kale, cabbage, broccoli, legumes, jicama, and other plant foods. You also can find oligosaccharides in berries, pears, figs, bananas, nectarines, and watermelon as well as in wheat, rye, peas, and beans.
Can Avazza be given to young children?
Yes, children over 3 years old can safely consume Avazza to help improve gut health.
Can Avazza be used to improve gut lining integrity?
Advanced technology has shown that the fermentation products of HMOs made the gut lining less “leaky.” A leaky intestinal barrier has been linked to gut conditions such as coeliac disease, Crohn’s disease, and irritable bowel syndrome as well as a range of conditions affecting the rest of the body.
These studies provide scientific evidence that HMOs may be used to develop strategies to counter these conditions and improve gut health in adults.
A little SCIENCE HERE! A Recent clinical Trial…
A recent clinical trial showed that two specific HMOs, 2′-O-fucosyllactose (2’FL) and/or lacto-N-neotetraose (LNnT), are safe and well-tolerated in adults and are modulators of the adult gut microbiota with an increase in bifidobacteria.
This suggests that HMO supplementation may be a valuable strategy to modulate health in adults.
To address this, a collaboration was established between the Quadram Institute, a food and health research center in the Norwich Research Park, UK, and Glycom, a Danish-based biotechnology company, and the world’s leading supplier of HMOs.
Their study, published in the journal Nutrients, was partly funded by the Biotechnology and Biological Sciences Research Council (BBSRC).
A Simulator of the Human Intestinal Microbial Ecosystem (SHIME®) was used to determine the influence of HMOs on the adult gut microbiota composition and function.
These experiments were performed at ProDigest, a spin-off company from the Center of Microbial Ecology and Technology (CMET), located at Ghent University in Belgium.
The results showed that fermentation of 2’FL, LNnT and combinations thereof led to an increase of bifidobacteria, accompanied by an increase of short-chain fatty acids.
Prof. Nathalie Juge’s team in the Quadram Institute then used the products of this fermentation to study the influence of fermented HMOs on the intestinal barrier function of cell lines and advanced gut-on-chip models.
Caco2 cells are a line of cells originally derived from the human gut and used extensively in research, with an arrangement of them into a single layer being an established model for studying the gut and its permeability.
A significant reduction in permeability was observed using Caco2 cell monolayers with fermented HMOs, accompanied by an increase in specific proteins known to help maintain barrier integrity, tight-junction proteins, and cytokines.